Presented with the evidence of Olivia's actions, President Allison Taylor is forced to make a decision between her family and the Presidency. Thanks to Kim Bauer, Janis, Renee and Chloe are able to save Jack and arrest Tony before he can kill Alan Wilson. With Wilson refusing to talk and Jack about to die, the fight is no longer in the field, it's for the hearts and souls of Jack and Renee.

Jack Bauer is forced to help Tony escape from custody, only to find Tony plans to use Jack to reconstitute the pathogen. Aaron Pierce and Ethan Kanin work together and discover Olivia's role in Hodges' murder. Kim Bauer takes down her captors, and works with Renee Walker to find her father.

Jack and the FBI must secure the biological weapon before it is released on the subway, Olivia is forced to make the transaction on Jonas Hodges murder in order to be protected, and Kim suspects she is being followed at the airport. There is friction between Chloe and Janis at the FBI. Later, Jack is forced to help the terrorists in order to protect someone close to him.

Jack goes back into the field to help the FBI track down Tony and the bio-weapon canister, but his decaying condition begins to be a liability.

The nation remains vulnerable as Jonas Hodges' life lies in the balance, and his boss stands at the epicenter of the mounting terrorist threat. Meanwhile, Jack hurries to expose Tony Almeida's doublecross.

As Jack's pain worsens, he attempts to uncover the mole in the organisation; Renee is stunned by an unexpected death; and, with one canister of the virus still missing, Jonas Hodges is given an ultimatum by his bosses...

Hodges meets with President Taylor to outline his demands involving Starkwood having a seat at the highest government level, but Tony's plan to detonate Starkwood's weapons systems dramatically reverses the control of power.

Hodges threatens war on the FBI if they do not retreat from his property, but quick thinking by Tony and Moss shed new light on the whereabouts of the biological weapons.

Tony leads a group of FBI agents into Starkwood with the help of Hodges's aide, but finds that his intel might not be as accurate as he thought.

Jack and Tony manage to locate the incoming biological weapons, but must convince a civilian security guard to go along with their plan when men from Starkwood show up to claim the weapons.

Jack seeks Senator Mayer's help to help discover the connection between Juma and the company that hired the man who killed Burnett.

The siege on the White House reaches an explosive end after Jack and Bill work together to try and save President Taylor.

Juma and his men take the White House by storm, killing most of the Secret Service and trapping Taylor and Jack in the saferoom. His efforts to extract her are thwarted until he is informed that the President's daughter is in the White House as well.

Jack and Tony hatch a plan to interrogate Burnett inside the White House, but it is interrupted when Senator Mayer and the President discover his activities.

Dubaku's attempt to flee the country is cut short when his decision to take his girlfriend along proves to be his undoing, and leads to a breakthrough for Jack and Renee.

Jack and Renee track a lead to Dubaku's unsuspecting girlfriend, who, after learning of his true motives, agrees to help lead them to Dubaku before he flees the country.

Jack and Bill win an audience with the President in order to secure the necessary clearance to continue their hunt for Dubaku.

Dubaku begins another strike against a chemical plant in Kidron, Ohio, but his plans are cut short when Jack's team arrives at his hideout. Janis helps the plant manager avoid any casualties by manually overriding the valves.

President Taylor is faced with an angry cabinet after an unpopular decision results in the loss of many American lives in a terrorist attack.

Jack and Tony use creative means to force Matobo out of his saferoom and prepare to leave with their prisoner when Agent Walker arrives on the scene, prompting Emerson to make some quick decisions.

Buchanan takes Jack to "CTU", a secret hideout where he and Chloe had been working with Tony to uncover the conspiracy within the US government. Tony had been undercover with the terrorists aiding Juma to discover the moles. Jack agrees to help get Tony back in play by joining Emerson's crew himself.

With Tony in custody, Jack leads his interrogation, but is shocked when a code word Tony whispers in his ear leads to old friends and a plot much deeper than anyone in the FBI anticipated. Jack once again takes the law into his own hands when he breaks Tony out of the FBI's custody to deliver him back to the terrorist faction.

Tony and his crew put their CIP override device to the test as they divert two planes in mid-air, nearly causing a collision and hundreds of casualties. With the successful test of the device, Tony's boss, Emerson, delivers it to General Juma who is planning to use it to blackmail the US.

Season seven opens with Jack Bauer before the US Senate, defending his actions throughout his career with CTU, mostly involving human rights crimes and torture of suspects. He is pulled away by FBI agents Renee Walker and Larry Moss, who need his help to quickly locate Tony Almeida, once thought dead, who appears to be masterminding a terrorist plot to override the government's CIP firewall and cause massive damage.