The team investigates the particularly gruesome outcome of a 21st birthday where the party plans became all but anything worth celebrating. With just a few and not easy answers as their only lead in the case, the CSis are challenged to stretch their abilities to the limit.

The CSIs get immersed in the world of F1 racing to investigate the death of a racing legend pilot in a car explosion two days before a Grand Prix Race. Soon they'll discover that speed, adrenaline and sponsors aren't always all that comes into play in the the professional racing community in general and the Seraphim Racing Team in particular.

The CSIs team found themselves involved into the obscure world of modern vampirism cult in which blood sharing is at the core of an eccentric but allegedly spiritual brand of religion as a young woman is found dead by exanguination in the Central park snow, with her earlobe chopped and a puncture wound in her neck.

After the beautiful young star quarterback on a Lingerie Football team is found dead in the locker room whirlpool with traces of lidocaine, the team realizes that competition is not all that clean. From a trainer with a shady past involving steroid violations, to the rivalry between the team members to the world of plastic surgery, the team has to tread lightly to discover the truth behind a complex scenario of mixed interests and alliances.

Mac suddenly becomes unwillingly involved in the domestic life of a long-time friend and associate when he is revealed more than he would have wanted to know and gets to find out more than he could have suspected. At the same time, he struggles to honour the promise to bring the killer of a 18-year-old girl to justice.

The team learns that a man, who had been clean for two years, has been hit by a car and it seems that a 2 million dollar life insurance policy was behind his death. On the other hand, they have a hard time figuring out how a second victim died because of identity theft and if the two deaths are linked.

As a consequence of a 911 call, Mac and the team find themselves in a vacant penthouse. However, they discover something else that takes the case into a different direction. Now they have to not only find the caller but also solve the mystery of an unearthed 100 year old corpse as they navigate their way through a booby-trapped house.

Danny is back in the field with Flack for the first time after the shooting and a store owner's life is in the balance. Mac finds a key piece of evidence that will put him in the path of serial killer.

Which presumably seemed to be a traffic accident, turns out leading to homicide and illegal organ harvesting. The chase of those involved in the slaughter chain makes all three NY, Vegas and Miami CSI teams put their efforts together to put an end to the crimes. Hawkes, in particular, is very upset about the case.

Hawkes may find himself in trouble after a man dies. The team finally finds out why Hawkes kept asking for overtime.

Mac and his team have to help a dancer remember the events that lead to the death of her boyfriend in their hotel room after winning a large sum in a street dance battle. They also have to find answers to why the hotel manager didn't bother to assist the woman when she rang the bell and why the money was left untouched.

A woman confesses to murdering her husband but when the evidence is tested to see if she is telling the truth, it clears her of any wrong doing taking the case in a completely different direction and leading to several potential suspects, a serial killer striking in the city among them. Mac sets his mind out to find who the woman is protecting.

A man who has apparently committed suicide is found hanging from a window on Ellis Island. The team has to figure our how the death occurred.

Mac has to figure out why a mysterious caller keeps asking questions about his father and how he knows everyone's name.

Danny and Mac get the unexpected help of a young woman while trying to solve their most recent case involving a cop killing.