Cristina, Izzie and Meredith take care of Shane, a man who appears to be crazy and claims that he is pregnant. Shane's case induces a spreading fascination among the staff. George relates to a patient's husband. Meanwhile, Derek treats a girl in a wheelchair. Cristina and Burke discuss disclosing their relationship to the public. Alex gets interrogated about his feelings for Izzie. He encourages his patient to get surgery that could help her have a more normal life and she encourages him to fix things with Izzie. Derek and Addison go to couple's counseling.