It's Thanksgiving at Seattle Grace Hospital but the holiday's festivities are less than in order. Meredith and Derek try to counsel a family after their relative has had a seriously traumatic accident. The woman doesn't respond well to the ideas of medical diagnosis and treatment. Izzie is planning a big get-together but the RSVP isn't going so well. George goes turkey-hunting with his family. All that and lots of general socializing among the interns.