Meredith must make an important choice about which path she wants to follow to determine the future of her love life. While she considers her future, she and others have flashbacks of their pasts. Addison treats an infant who is in critical condition after being thrown in the trash on high school grounds, and she must deal with a group of 14-year-old girls and their parents to find out who is the teenage mother. Cristina spends time with Burke while he recovers. Webber and Adele have a conversation after he spends the night at the hospital. Everyone attempts to deal with Izzie's choice to quit, and George seeks relationship advice from Derek.