John Dorian, "J.D." to friends, is a boyishly handsome, self-deprecatingly funny, likable guy who would be confident if he only realized his assets. Four years of medical school have prepared J.D. for his first day as an intern at Sacred Heart Hospital - but he has his doubts. As J.D. is thrown into the chaotic world of hospital life, we not only get to see the quirky characters that he encounters, but also hear the humorous commentary of thoughts streaming through J.D.'s head.