After the fight between Jake and Sam, Dean has to make the ultimate sacrifice for his brother. Meanwhile the Yellow-Eyed Demon has his new servant and plans to unleash the hordes of Hell

Sam and other "special children" are abducted by the Yellow-Eyed Demon and taken to a ghost town, where the ultimate battle must start. Where as dean and bobby try to find a way of locating sam.

Dean is attacked by a Djinn... and finds himself in a new reality where his mother is still alive and a mysterious woman holds the key to everything.

A mysterious door has been opened in prison. Prisoners are now dying from heart attacks. It is Sam and Dean's job to find out what is killing the prisoners.

Sam and Dean discover that a group of ghosts are murdering the crew of a horror movie.

Sam and Dean investigate a brutal death and discover that the killer is a lycanthrope: a werewolf.

A woman named Molly and her husband are driving down the highway and swerve to miss a farmer who's walking down the road. Their car hits a tree and when Molly wakes up her husband is missing. Sam and Dean discover Molly and find out that the farmer haunts

The Winchester brothers seek the help of their family friend Bobby while investigating a series of unexplained happenings on a local college campus.

Sam contacts Dean after being missing for a week. When they reunite, Dean finds Sam covered in blood and with no recollection of what happened.

An angel causes people to cheerfully go out to murder, and when the Winchesters investigate one of them falls under its sway.

The Winchesters investigate a series of crimes where robbers with no criminal past commit suicide after the hold-ups.

Sam and Dean investigate an Connecticut inn run by a single mother where mysterious deaths are taking place. They find evidence of Hoodoo, and try to figure out who is causing the chaos.

Sam meets a woman who shares his ability to have visions, and she warns him that she has seen the future... where he dies in an explosion.

Sam has a vision of Dean shooting a defenseless man, and they go to the town of River Grove, where they find the townspeople have been possessed by a virus that makes them violent.

Dean calls a demon to make a deal to save a man named Evan Hudson, in exchange for himself. While making the deal, the demon confronts Dean’s worst nightmare about their dad.

Sam and Dean investigate the murders of a lawyer and his wife who claimed to have seen a ghost right before they died. However, after local detectives Ballard and Sheridan uncover the Winchesters' records, they arrest the brothers for a double homicide

Sam and Dean investigate the slayings of blonde women and find that the ghost of the first known serial killer in US history is responsible. Jo disobeys Ellen's wishes and follows them along, and is captured by the ghost.

Sam and Dean meet Andy Gallagher, a slacker with psychic powers of persuasion. Once the brothers learn that Andyís family was visited by the Demon, Sam wonders if he could be one of the special children.

Dean and Sam investigate the death of a young college student who died in a car accident, but whose grave is now surrounded by a circle of dead plants.

Sam and Dean encounter a vampire hunter whose obsession may get them all killed.

After the events at the hospital, the brothers have no idea where the demon that killed their mother is hiding. While biding their time trying to come up with an idea, they investigate murders committed by a killer clown.

In the aftermath of the car crash, the surviving Winchesters go to the hospital, where one is stalked by a Reaper while another must consider sacrificing himself to save the others.