While searching for a monster, Dean, Sam and Bobby run into Gwen and Samuel (Mitch Pileggi); Samuel and Bobby have a heated argument.

After Raphael attacks Castiel and his allies, Balthazar tries to protect Sam and Dean by sending them to an alternate universe.

Dean rushes home after hearing that Lisa is in trouble; Sam investigates murders that were part of a cruel joke.

Sam has flashbacks of a case he worked with Samuel; Sam and Dean follow the coordinates received in a text message to a small town, where Sam used to live; townspeople's comments surprise Dean.

Bobby and Dean wait to see if Death was able to restore Sam's soul without complications; Dean must prove himself worthy of receiving the only weapon in the world that can slay a dragon.

After young girls go missing, Dean and Sam realize vampires have come to town; Dean is bitten during a fight with two vampires.

Bobby asks Dean and Sam for help after Crowley refuses to return Bobby's soul; a deep secret about Crowley is revealed.

Sam investigates when the parents of missing babies are murdered; Dean reluctantly leaves Ben and Lisa to help Sam.

The sixth season begins with Sam being released from hell and trying to convince Dean to rejoin him in fighting evil. To help persuade him, Sam introduces Dean to a new family led by their grandfather Samuel (Mitch Pileggi).