As the CBI investigates the murder of a young girl and the abduction of her twin sister, everything points towards Red John's return. However, Patrick Jane thinks somebody else is involved as well.

Patrick Jane must find a way to convince a group of students at a wilderness program for troubled kids to tell him the truth about the circumstances leading to the death of one of their fellow students.

When the CEO and founder of a software company vanishes from his yacht, Jane and the CBI team are asked to investigate.

Jane and the CBI set out to determine who is responsible for the Mob-style execution of a man in the Witness Protection Program.

CBI investigates the murder of Hollywood movie producer Felix Hanson. Evidence leads to the belief that drugs are involved, but further investigations indicate a connection to a running movie production of a film called "A Dozen Roses".

Jane and the CBI track down a person, who hypnotizes people into doing the dirty work for them.

The CBI investigates a written threat when the personnel director of Carnelian Inc. plummets to his death at Jane's feet during a skydiving exercise.

When Patrick is left temporarily blinded after an explosion, he finds himself using unusual methods to investigate the death of a financial advisor that somehow seems to be connected to himself.

A woman is poisoned at a country club, while a party is in full swing, so the CBI is called to investigate. The team soon finds out, that each of the suspects is hiding something.

The CBI goes to investigate the death of a married woman, who was murdered while in bed with her lover.

A business tycoon's son-in-law is found dead near where a $50 million painting once hung in his father-in-law's office. Jane and the CBI try to find out how he might have been involved and who else is responsible.

When Cody Elkins, a high school football star, is found murdered, all trails point to the local witch, as her motive could be revenge for Cody stealing, torturing and killing her cat. When the CBI goes to investigate, she admits to having put a killing spell on Cody, but Jane still shows skepticism.

A convicted murderer convinces Jane to help prove his innocence by telling Jane that he would give him information on Red John. Jane quits CBI to devote all of his time to getting him released.

Patrick Jane becomes very interested in a new case involving his former psychiatrist, who is the victim's ex-wife and also the prime suspect.

A murder in a small town is investigated and soon turns out to be an act of vengeance.

CBI are called to a murder scene, when the State's witness in a drug trial and a girl are found dead in a motel room. Local police are quick to decide that Rick Carass, the drug dealer on trial, is behind the murder, but Patrick Jane thinks otherwise.

When Rosemary Tennant becomes the victim of a hit and run, Patrick Jane takes on her psychic adviser, who claims to have foreseen her death, as he thinks she is a fraud.

A severed hand is found on the California-Nevada state line, that belongs to a murdered hotel casino owner. While the CBI team suspects a mafia hit, Patrick Jane uses the investigation as an opportunity to win at the cards tables.

A girl is found stabbed to death in the woods, and her best friend is missing. She is found covered in blood with a knife in her hand, which makes her the prime suspect, but she is suffering from memory loss. Patrick Jane uses his mentalist skills to help find out what really happened.

Jason Sands, a wealthy banker and political contributor is found dead inside his residence vault. After being tortured, he had bled to death in his vault. Patrick and the team delve into Jason's private life to find the murderer.

A drowned girl's body is found on the Santa Marta beach, and many of her surfer friends are suspects. When interviews lead to nothing, Patrick uses his skills to determine and catch the killer.

The CBI is called in to investigate the murder of a young woman, found tied up and dumped in a Northern Napa County vineyard. Lisbon focuses on the theory that this was the result of a lovers' quarrel, but Jane believes this may be the work of a serial killer. He investigates his own theories and gets the team's assistance with a plan to catch the killer.

This episode introduces us to the complex life of Patrick Jane, a police detective with a troubled past who has a keen eye for detail. When a man and woman are found dead in their home, many believe they are victims of a serial killer, but Patrick knows better and must prove that this was not the work of Red John.