Anna is focused on having Lisa breed with Tyler to ensure the evolution of the Visitors, while Erica and Diana enlist Lisa to stage a coup against Anna and remove her from power before humanity is destroyed.

The Fifth Column tries to figure out Anna's plans for the Blue Energy reactor; Diana tells Lisa that the time to fulfill her destiny is upon her.

Erica, now officially in charge of the global Fifth Column, leads them in a high risk attack against Anna. Anna meanwhile, growing closer in her plan to destroy humanity, finds a major obstacle in a certain Live Aboard candidate; and Ryan sneaks back onto the Mothership to try and rescue his daughter,

Erica, seeking revenge against Anna, heads to Hong Kong to carry out a mission to strike a lethal blow against Anna. Meanwhile, Anna learns that Tyler's phosphorous level is too low - even after the Red Rain -- and he might become useless to her; and Lisa and Diana bond, beginning to form an alliance against Anna

Anna enlists Ryan to help in efforts to eliminate the Fifth Column; the Vatican orders Father Travis to have Jack leave the church; Lisa meets her grandmother.

Anna uses Concordia to hide a fleet of breeding vessels; Eli Cohn tries to convince the Fifth Column to assassinate Anna during the gala.

After three Peace Ambassadors are murdered by the radical fraction of the Fifth Column, Erica tracks their leader; Anna visits the Vatican.